Similarly, matrix metalloproteinase-2 (MMP2), a known contributor to ECM proteolysis in MFS aortic aneurysm development in MFS27–31 was increased in all MFS LM SMC lines (mean ratio 1.53, range 1.26–1.98), while MMP2 was stably expressed in control LM and NC lineages (mean ratio 0.96, range 0.85–1.08). Here, MMP2 is linked to aortic aneurysm.