LISA cistrome analyses73 of the PGC1α-dependent genes (Supplementary Figure S4) revealed that the top 50 transcription factors associated with these DEGs included 5 nuclear receptors (AR, NR3C1, ESR1, PR, PPARG) as well as known pioneer and lineage-determining transcription factors implicated in PCa, including FOXA1, GATA2, HOXB13, FOXA2, CEBPB and SOX4. This evidence concerns the gene ESR1 and posterior cortical atrophy.