TARDBP and Alzheimer disease: However, although we showed that TDP-43 induced both Aβ40 and Aβ42 toxicity in LTP and in water maze study in the injection mice model and demonstrated that both Aβ40 and Aβ42 colocalized in brain of post mortem AD patients, the exact molecular interaction of TDP-43 to Aβ40 and Aβ42 needs to be further investigated to elucidate potential differences resided in Aβ40 and Aβ42.