ENPP2 encodes ectonucleotide pyrophosphatase/phosphodiesterase 2(ENPP2), also known as Autotaxin, and catalyzes the generation of the lipid-signaling molecule lysophosphatidic acid (LPA)24, which participates in the development of the nervous system and tumor progression25,26. Here, ENPP2 is linked to neoplasm.