CD8A and infection: It is also worth noting that recombinant Crimean Congo Hemorrhagic fever virus (CCHFV) nucleoprotein was previously shown to have multiple CD8 + T-cell epitopes31 and that mice surviving Crimean Congo Hemorrhagic fever virus (CCHFV) challenge, were found to have CD8 + T-cells that could secrete IFN-γ years after infection (by ELISpot in response to peptide stimulation), thereby confirming the role that these cells have in the host immune response.