To further validate our findings, we conducted lipidome mass spectrometry analysis on Ficoll-purified primary bone marrow mononuclear cells of aCML patients, either positive (3) or negative (3) for ETNK1 mutations, evaluating 10 of the most important lipid classes. Here, ETNK1 is linked to atypical chronic myeloid leukemia, BCR-ABL1 negative.