IHC was used to evaluate the correlation between DZIP3 expression and CD31 (a novel angiogenesis marker) [14]; DZIP3 mainly expressed on vascular endothelial cells and was negatively associated with CD31 at the protein level indicating that DZIP3 could affect the angiogenesis process of glioma (Figure 3A). Here, DZIP3 is linked to glioma.