Among them, SRD5A1 [11, 12], SRD5A2 [13, 14], adenosine kinase (ADK) [25], Dynamin 3 (DNM3) [26], miR-125b-2-3p [27], miR-130a-3p [28], miR-126-5p [29], miR-450b-5p [30], miR-186-5p [31], miR-139-5p [32] and miR-342-3p [33] have been reported to influence the growth, invasion, metastasis or drug resistance of HCC. The gene discussed is ADK; the disease is hepatocellular carcinoma.