SRD5A3 and cancer: Moreover, we also explored the prognostic significance of SRD5A3 in other cancers, and found that the high expression of SRD5A3 was associated with the poor OS rates of skin cutaneous melanoma (SKCM, P = 0.00034), kidney renal clear cell carcinoma (KIRC, P = 0.023), kidney renal papillary cell carcinoma (KIRP, P = 0.018), uveal melanoma (UVM, P = 0.0071), brain lower grade glioma (LGG, P = 0.037), breast invasive carcinoma (BRCA, P = 0.041), thyroid carcinoma (THCA, P = 0.036), and glioblastoma multiforme (GBM, P = 0.048) (Figure 6A–6H).