PLK1 and hepatocellular carcinoma: Furthermore, correlation exploration in the present study hinted that SRD5A3, together with other members of steroid 5-alpha reductase enzymes (SRD5A1 and SRD5A2), may also be correlated with other molecules, such as PPIAP22, EIF3K, KIAA1522 and etc. Moreover, the effect of SRD5A3 on HCC growth may involve the regulation of the cell cycle through CDK5, CDK4, CDK7, CDKAL1, CCNB1, CDK1, and PLK1.