Therefore, the levels of the related hormones (E2 and progesterone in serum, and ALLO in the hippocampus), emotion-related neurotransmitters (5-HT, NE, and GABA in the hippocampus), and the expression of GABRA4, which is essential to the pathogenesis of PMS/PMDD [26], were determined (Figures 7‒9). This evidence concerns the gene GABRA4 and premenstrual tension.