In ACPA-negative RA patients, absolute DAS4 months was predictive for SDFR development, OR0.44 (95%CI, 0.29–0.68), in a model that included baseline DAS (this analysis still mimicked ΔDAS0–4 m), and also in a model without baseline DAS, OR0.51 (95%CI, 0.35–0.75) (Table 2, supplementary Table S6). This evidence concerns the gene PRTN3 and rheumatoid arthritis.