DNMT3A and amyotrophic lateral sclerosis: While studying ALS (amyotrophic lateral sclerosis) in mouse, another neurological disease affecting voluntary muscle movements, researchers have found the presence of the enzyme DNMT3A in the CNS (central nervous system), striated muscle and testes of these animals, and reinforced these findings by detecting the same enzyme in mitochondria of human cerebral cortex [49, 55].