TFB1M and cancer: Research in mice and human cancer cell lines have shown an association between rRNA hypermethylation, an activation of the proapoptotic transcription factor E2F1 and faulty mitochondrial biogenesis in respect to two mitochondrial regulatory proteins: the rRNA methyltransferase-related human mitochondrial transcription factors B1 (h-mtTFB1) and B2 (h-mtTFB2) [30, 33, 34].