FZD5 and polycystic ovary syndrome: Simultaneously, several genes of the Wnt signaling pathway, specifically FZD1, SFRP1, and WNT10B, were consistently downregulated in PCOS cells over time (Additional file: Supplemental Fig. 7D–F, right panel), with the role of Wnt10B in stabilizing β-catenin to inhibit glycogen synthase kinase 3 and adipogenesis [46] and in suppressing Wnt receptors, including Fzd1, Fzd2, and Fzd5, during adipocyte differentiation [47].