Conversely, a transcriptional repressor of the androgen receptor (AR), ANKRD1, as well as genes involving the Wnt signaling pathway, FZD1, SFRP1, and WNT10B, were downregulated in PCOS cells compared to control cells (Additional file 2: Supplemental Fig. 7C–F, right panel). Here, FZD1 is linked to polycystic ovary syndrome.