In SC abdominal ASCs of normal-weight PCOS women compared to controls, the significant enrichment over time of motifs from the AP-1 family (c-Jun, c-Fos, Jun-B, Fos-B, and Fra-1), a critical TF involving adipocyte differentiation [32, 33] implies their critical roles in accelerated adipogenesis in vitro, as previously described in PCOS ASCs [25] (Additional file 3: Supplemental Table 2). The gene discussed is FOS; the disease is polycystic ovary syndrome.