The main findings of this retrospective study were the following: (1) BE-RLD and OM-RLD showed good clinical outcomes at 1 year after surgery, (2) BE-RLD performance resulted in significant improvement in pain and patient satisfaction up to 2 weeks after surgery, and (3) the peak serum CRP and CPK values were significantly higher in the OM-RLD group and took longer to recover to the normal range. The gene discussed is CRP; the disease is ocular melanoma.