Currently, programmed death ligand 1 (PD-L1) expression on tumor cells [4, 5], tumor mutation burden (TMB) [6, 7], tumor-infiltrating lymphocytes (TILs) [8], microsatellite instability (MSI) [9], tumor microenvironment (TME) [10], and microbiome [11] are factors taken under consideration when administering immune checkpoints inhibitors to NSCLC patients. Here, CD274 is linked to neoplasm.