While Fig. 6 shows the interaction network, which indicates HSPB1, ITPKB, CRYAB, ACTN2, FERMT3, NEFL, POU4F2, RIT2, and PLXNB3 are closely related to HTT and may serve as pivotal points exerting consequences of HTT-polyQ mutation in HD. The gene discussed is HSPB1; the disease is Huntington disease.