While Fig. 6 shows the interaction network, which indicates HSPB1, ITPKB, CRYAB, ACTN2, FERMT3, NEFL, POU4F2, RIT2, and PLXNB3 are closely related to HTT and may serve as pivotal points exerting consequences of HTT-polyQ mutation in HD. This evidence concerns the gene POU4F2 and Huntington disease.