Univariate and multivariate analyses showed the proportion of CD8+ PD-1High (P = 0.025, HR = 1.557, 95% CI 1.057–2.292) within CD8+ PD-1+ T cells in tumor was the independent prognostic factor for OS in ICC patients (Table 2). This evidence concerns the gene PDCD1 and intrahepatic cholangiocarcinoma.