CD8+ PD-1High T cells comprised TNF-α and IL-2 expression, indicating that the production of cytokines and anti-tumor ability were generally defective, while CD8+ PD-1High T cells upregulated the expression of immunosuppressive cytokine IL-10, suggesting that CD8+ PD-1High T cells may obtain the ability to inhibit the immune response in HCC [17]. Here, TNF is linked to hepatocellular carcinoma.