In this study, we investigated CD68+ in macrophages, CD8+ T cells, and PD-1/PD-L1, as well as immune cell subgroups classified on PD-1/PD-L1 expression, for their association with clinical features and prognosis of ICC patients, providing some meaningful information for ICC oncological research. Here, PDCD1 is linked to intrahepatic cholangiocarcinoma.