VEGFA also facilitates the invasion of cancer cells via the VEGFA/VEGFAR pathway by activating p38 mitogen-activated protein kinase MAPK and phosphatidylkinase B (AKT) in order to induce MMP expression, which are widely used to indicate the metastatic capability of colon cancer cells [21]. The gene discussed is VEGFA; the disease is malignant colon neoplasm.