Nevertheless, we aimed to again validate the context-specific gene essentiality of HAP1 cells on genes involved in the Fanconi anemia pathway using an approach independent of a DNA damage response and therefore again performed an siRNA knockdown for four genes of the Fanconi anemia core complex, FANCE, FANCM, FANCG, and FANCL (Additional file 15: Fig. S10 B-C, Additional file 16: Table S4). This evidence concerns the gene FANCE and Fanconi anemia.