More importantly, the rapid growth of tumours is often accompanied by hypoxia, and hypoxia inducible factor (HIF), as the key regulator of glycolysis, can solve the nutritional needs of tumour cells by inducing the expression of glucose and amino acid transporters (glucose transporter type 1 (GLUT1)) and L-type amino acid transporter 1 (LAT1) to further promote the progression of cancer [20, 21]. This evidence concerns the gene SLC7A5 and cancer.