PFKFB4 and Familial prostate cancer: 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), is a key kinase in Warburg pathway [34], has been found to be associated with a variety of cancers, including breast cancer [35], prostate cancer [36] and glioblastoma [37], promoting the progression and metastasis of cancer, and may become an effective molecular target of anti-tumor drugs.