Patients were stratified into five subgroups according to age, ER/PR, T stage and tumor location, and 5-year LRR were 1.7, 3.4, 3.8, 14.4 and 20.0% for patients with 0, 1, 2, 3, and 4 risk factors, respectively (Fig. 2). This evidence concerns the gene ESR1 and neoplasm.