By screening the coding region of SEPT14 in donors of male infertility (n = 254) and normal controls (n = 116), six donors with SEPT14 mutations, SEPT14A123T (n = 3), and SEPT14I333T (n = 3) were identified, which showed morphological defects of the sperm head [38]. The gene discussed is SEPTIN14; the disease is male infertility.