Thus, irrespective of the presence of hypotonicity, almost all causes of hyponatremia (except for low dietary solute intake, renal failure, primary polydipsia, or beer potomania syndrome) are accompanied by increased ADH, mainly due to the syndrome of inappropriate ADH secretion (SIADH) or to effective circulating volume depletion. The gene discussed is AVP; the disease is Hyponatremia.