HTR1A and depressive symptom measurement: Along with its anxiolytic properties, CBD displayed antidepressant efficacy in animal models of depression, inducing an antidepressant-like effect when given alone [137] or in combination with sub-effective doses of the antidepressants fluoxetine or desipramine [136], mainly through the activation of 5HT1A serotonergic receptors [137].