PNPLA3 and metabolic dysfunction-associated steatotic liver disease: As for the genetic substratum, the polymorphism of I148M PNPLA3 gene (patatin-like phospholipase domain containing 3) is the major determinant of NAFLD, whilst the transmembrane 6 superfamily member 2 gene (TM6SF2), the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7), and the glucokinase regulatory protein (GCKR) variants play a minor role [6].