Numerous studies have explained that the aerobic glycolysis of cancer cells is commonly linked to chronic overactivation of the hypoxia-inducible factor-1 (HIF1), which boosts the expression of glycolytic enzymes and pyruvate dehydrogenase kinase-1 (which inhibits pyruvate dehydrogenase and thus accelerates a conversion of pyruvate to lactate) and promotes mitochondrial autophagy [60,61,62]. Here, PDK1 is linked to cancer.