Indeed, when calculating cell scores of different immune cell subsets by the expression of mRNA markers specific for each cell type relative to CD45 mRNA levels (cell type/tumor infiltrating immune cells), scores for T cells (CD3D, CD3E) and cytotoxic cells (PRF1, KLRK1, KLRB1, GNLY, GMZA) were marginally lower, but cell scores for CD8+ T cells (CD8A) and macrophages (CD84, CD163, CD68) were higher (Figure 3). This evidence concerns the gene CD3D and neoplasm.