PTEN and neoplasm: In contrast, genes with immunosuppressive functions like VEGFA, HIF1α, CD47, CD74, and CD44, as well as signaling pathway-associated molecules like AKT, PTEN, STATs, and CTNNB1 coding for PI3K and WNT signaling, were highly expressed in both tumor cell (EPCAM and MultiKRT) and immune cell (CD45)-enriched regions (Figure 4B and Figure 5).