Strome et al. also reported that BMDCs loaded with irradiated E.G7 tumors (100 Gy), which express the OVA antigen, can promote the activation of the adaptive immunity by specifically generating OVA-specific IFN-γ-producing CD8+ T cells; treatment with these cells imparted significant protection in two analogous human melanoma models [34]. The gene discussed is IFNG; the disease is melanoma.