This complement activation leads to enhanced production of endothelial-production of cytokines, such as IL-1, IL-8, RANTES, IL-6, and MCP-1, and up-regulates crucial endothelial adhesion molecules, such as P-selectin and VWF, which further helps to develop thrombin formation in COVID-19 patients [102]. This evidence concerns the gene VWF and COVID-19.