Altogether, with COVID-19 patients’ pathological studies, ACE2 expression in the heart, and significant resemblance of SARS-CoV infection with COVID-19, the possible mechanisms of myocardial injury in COVID-19 could be direct systemic inflammation, exaggerated cytokine response by immune cells, hypoxia, DIC, myocardial fibrosis, and direct damage to the cardiomyocytes. Here, ACE2 is linked to COVID-19.