Moreover, through polyploidy, the TP53 cancer mutants can acquire the phenotypical features of more ancient unicellular eukaryotes (“amoeboidisation”) [24,27,33,108,113,114], in line with the atavistic theory of cancer [29,30,33,115,116], confirmed by gene phylostratigraphic analysis [38] and here. Here, TP53 is linked to cancer.