KEAP1 and lung carcinoma: Another protective mechanism observed in lung cancers is metabolic reprogramming to glutaminolysis, mostly observed in KRAS (Kirsten rat sarcoma viral oncogene homolog)-mutant lung adenocarcinoma, which exerts a loss of STK11/LKB1 (serine/threonine kinase 11, liver kinase B1) and co-occurring KEAP1 mutation [56].