HSP90AB1 and medullary thyroid gland carcinoma: In medullary thyroid carcinoma cells, nelfinavir reduced the level of HSP90 client proteins E-cadherin, SRC, and connexin-43 which was associated with inhibited adhesive property of the cancer cells, leading to the reduced spheroid formation and induction of anchorage-dependent cell death (anoikis) [38].