A widely used anti-malarial drug chloroquine is an inhibitor of late-stage autophagy and has been used in combination with nelfinavir to demonstrate enhanced cytotoxicity in chronic lymphocytic leukemic cells [77], tuberous sclerosis negative (Tsc2−/−) MEF cells, and human lung cancer cells (NCI-H460) [69]. This evidence concerns the gene TSC2 and lung carcinoma.