Liu et al. observed a resensitization of doxorubicin-resistant chronic myeloid leukemia (CML) cells during co-treatment of suboptimal doses of nelfinavir with doxorubicin, which resulted in increased apoptosis associated to caspase-3 cleavage, increased proapoptotic protein Bax, and decreased anti-apoptotic protein Bcl-2 [45]. Here, CASP3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.