Decreased Akt phosphorylation in response to nelfinavir was also evident in MM [37,73], AML [74], pediatric refractory leukemia [44], diffuse B-cell lymphoma [95], doxorubicin-resistant breast cancer [60], prostate cancer [46,48], and NSCLC [19,47]. Here, AKT1 is linked to prostate carcinoma.