We found that overexpression of L1 in CRC cells induces the expression and nuclear accumulation of ASCL2, a decrease in E-cadherin levels, and increased levels of β-catenin in the nucleus, together with elevated β-catenin-TCF transactivation of Wnt/β-catenin target genes [52]. The gene discussed is ASCL2; the disease is colorectal carcinoma.