KIT and colorectal carcinoma: While these dramatic effects of c-KIT on metastasis and cell motility indicated a tumor suppressive effect played by c-KIT [42], the proliferation in vitro and in vivo (in mice) of c-KIT overexpressing CRC cells showed that c-KIT enhances tumorigenesis, thus pointing to distinct modes of action of c-KIT in early versus late phases of tumor progression.