Because a great number of genes that are induced by L1 overexpression in CRC cells are coding for either membrane bound proteins and are exposed to the extracellular milieu, or proteins secreted into the culture medium (see above, IGFBP-2, CLU, neprilysin, SMOC-2), we conducted a proteomic analysis of the secretome from L1 expressing CRC cells. The gene discussed is SMOC2; the disease is colorectal carcinoma.