In the subgroup of patients with oropharyngeal cancer, the pre-treatment AST/ALT ratio was identified as significant predictor of CSS (HR 1.94, 95% CI 1.42–2.66; p < 0.001) and OS (HR 1.88, 95% CI 1.48–2.39; p < 0.001). Here, GPT is linked to oropharynx cancer.