Molluscan HS inhibited lung metastasis (10 foci/lung control vs. 1 foci/lung HS; p < 0.05) w markedly smaller tumor size, and reduced heparinase activity (p < 0.05); reduced tumor–platelet complex to 30% (control 70%); similar effect to mammalian heparin at lower molar concentration; blocks both P-selectin-mediated interactions and heparinase activity blunting metastasis and inflammation. This evidence concerns the gene SELP and neoplasm.