Nevertheless, on one hand, CK7 is also expressed in about 10% of CRCs [14] and CK20 and CDX2 markers can be lost in some CRCs, especially in those harboring MMR-d [15], while on the other hand, a fraction of SBAs (34%) have been reported to show a colorectal cancer-like immunohistochemical profile (CK7−/CK20+/CDX2+) [16]. The gene discussed is CDX2; the disease is colorectal cancer.