CD69 and neoplasm: On the contrary, the increased fraction of Th cells defined as Tregs in tumour compared to normal tissue was instead paralleled by a decreased fraction of these cells in blood of CRC patients compared to controls, and the decreased fractions of T cells expressing CD69 or NKG2D in tumour compared to normal tissue, was paralleled by an increased fraction of these cell subsets in blood of CRC patients compared to controls (Figure 1a,b).