Thereafter, abundant proteins, such as myelin basic protein (MBP), fibrin, vimentin and GFAP, were also demonstrated to be targets of this post-translational modification, in several pathological contexts, such as multiple sclerosis, rheumatoid arthritis and Alzheimer’s disease [27,89,94,95,96]. This evidence concerns the gene VIM and early-onset autosomal dominant Alzheimer disease.