A multi-site study using aptamer-based SomaScan proteomics to assay two FSHD populations identified a total of 115 proteins that were dysregulated, four of which behaved consistently between the two independent cohorts (creatine kinase MM, creatine kinase MB, carbonic anhydrase III, and troponin I type 2) [104]. This evidence concerns the gene CA3 and facioscapulohumeral muscular dystrophy.