MYC binds to ATF3 as well as to lysine-specific demethylase 5B (KDM5B) and YY1, all four of which are elevated in FSHD [9,79,80,81]; in addition, MYC is known to activate transcription of both enhancer of zeste homolog 2 (EZH2) and miR-9 [82,83], both of which are also increased in FSHD. Here, MYC is linked to facioscapulohumeral muscular dystrophy.