Consistent with such an inflammatory gene signature in FSHD, bioinformatic analyses here show five of the candidate miRNAs have established connections with TLR4 signaling, are increased in FSHD patients, and have gene promoters that are bound by AP-1 and/or NF-κB. The gene discussed is NFKB1; the disease is Facioscapulohumeral dystrophy.