The HCC patients with at least one polymorphic C allele (C/T + C/C genotype) of MMP-11 SNP rs738792 were prone to develop moderate to severe liver failure [22], and patients of OSCC with at least one polymorphic C allele of MMP-11 rs738792 were found to be associated with an increased incidence of lymph node metastasis [20], compared with the homozygous T/T genotype. The gene discussed is MMP11; the disease is Hepatic failure.