Although the direct impact of MMP-11 gene polymorphisms on the biochemical recurrence of prostate cancer was limited, patients with at least one polymorphic C allele (TC/CC) in rs131451 were associated with a higher risk of advanced-stage tumors and high-risk D’Amico classification compared with those with the wild-type homozygous (TT). The gene discussed is MMP11; the disease is prostate carcinoma.