To clarify the role of MMP-11 gene polymorphisms in the clinicopathological characteristics of prostate cancer such as clinical staging, pathologic staging, pathologic Gleason grade group, invasion and D’Amico risk classification, the distribution frequencies of the clinicopathological characteristics and MMP-11 genotypic frequencies in 578 patients with prostate cancer were estimated. The gene discussed is MMP11; the disease is prostate cancer.