Proangiogenic effects have been demonstrated also for activated EGFR (pEGFR) displayed on sEVs originating from other cancer cell lines, including A431, A549 and DLD-1, which, in turn, can induce the activation of MAPK and Akt signalling and initiate an autocrine VEGF signalling loop in recipient endothelial cells. This evidence concerns the gene EGFR and cancer.