EGFR and head and neck squamous cell carcinoma: In EGFR-overexpressing HNSCC cell line A431, instead, the desmosomal cadherin desmoglein-2 (Dsg2), which can activate EGFR through a c-Src/Caveolin-1-dependent pathway [179], has been found to be expressed on sEVs and regulate the packaging of both EGFR and c-Src.