This subversion, whereby astrocytes undergo changes in their proteome that favour the secretion of angiogenesis factors and the degradation of basement membranes to aid glioblastoma invasion, is achieved through the activation of MYC and p53 signalling pathways in recipient cells, where EGFR has been identified as one of the predicted upstream regulators of the network [181]. This evidence concerns the gene EGFR and glioblastoma.