EGFR and lung carcinoma: Finally, in human NSCLC cell line A549, EGFR is expressed on sEVs in a trimeric complex with receptors TrkB and sortilin [110], the former of which is another RTK that can cross-talk with EGFR family members in various cellular contexts [145,146,147], and the latter of which has been found to regulate EGFR signalling in lung cancer by promoting its internalisation [148] and is necessary for sEV release from the MVB pathway [110].