TNF and neoplasm: IL-10 exerts its role by binding to its receptor and blocking the anti-tumor immunity, inhibiting pro-inflammatory cytokines like IFN-γ, IL-6, IL-8, IL-12, IL-1β and TNF-α, suppressing the M1 polarization, and restraining the major histocompatibility complex II (MHC II) molecule on the surface of the macrophages [99].