INS and Insulin resistance: We demonstrated previously that Australian-bred Burmese (ABB) cats are at increased risk of developing T2D, and exhibit features typical of human T2D [5,6], including inadequate insulin secretion (dysfunctional β cells); impaired insulin action (insulin resistance) [7]; late age of onset; risk factors such as obesity and physical inactivity; islet vacuolation and amyloid deposition.