TNF and Sepsis: It has been shown that a low level of HDL-C negatively correlates with the severity of sepsis and is associated with a massive release of inflammatory mediators (i.e., tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8)) [59,60].