Several mutations in Cav3 protein (Arg26Gln, Ala45Thr, Ala45Val, Asp27Glu, Pro28Leu, Pro28Thr, Val43Glu, Leu86Pro, Ala92Thr, and Pro104Leu) have been associated with RMD [12,18]. This evidence concerns the gene CAV3 and inherited rippling muscle disease.