INS and metabolic disease: Although many effects remains to be clarified, it is evident that the increase in the activity of beige adipocytes is a consistent mechanism to increase glucose metabolism, supporting its role in treating obesity and related metabolic disorders in humans, especially for type 2 diabetes mellitus [255], which has two key pathophysiological components: peripheral resistance to the action of insulin especially in muscular cells and adipocytes and reduction in insulin secretion in β-pancreatic cells.