However, the results of in vitro studies have shown that the activities of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in addition to the functional modification of 5′AMP-activated protein kinase (AMPK) may be involved in resistin-mediated insulin resistance [122]. The gene discussed is IL6; the disease is Insulin resistance.