Surprisingly, however, in another study the stable knockdown of VDR expression leads to attenuation of the Wnt/β-catenin pathway in MDA-MB-231 breast cancer cells: cytoplasmic and nuclear levels of β-catenin are reduced with the subsequent downregulation of its target genes AXIN2, CCND1/cyclin D1, IL6, and IL8 [104]. The gene discussed is VDR; the disease is breast cancer.