CCND1 and intestinal neoplasm: Likewise, the antitumor action of 1,25(OH)2D3 on chemically induced mouse intestinal tumors is concomitant with increased expression of E-cadherin and the inhibition of β-catenin/TCF target genes such as c-Myc and Ccnd1/cyclin D1 in the intestinal crypts of these animals [85,86].