In addition, Gröschel and colleagues found that 1,25(OH)2D3 reduces nuclear β-catenin levels in LT97 colon microadenoma cells and thus downregulates the expression of Wnt target genes such as BCL2, CCND1/cyclin D1, SNAI1, CD44, and LGR5 [77]. Here, CCND1 is linked to digestive system cancer.