In addition to its effects on arterial and venous system, CT is effective in decreasing inflammatory mediators, such as interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and in increasing anti-inflammatory mediators, such as IL-10 and TGF-β so counteracting the negative effect of diabetes on these mediators [9,10]. Here, TGFB1 is linked to diabetes mellitus.