Dividing the LGG and HGG groups by their IDH1 mutational status, statistically significant differences were observed between the control and HGG (astrocytoma grade III and IV) groups as well as the HGG IDH1-wildtype and LGG IDH1-wildtype groups (p = 0.0203 and p = 0.0178 respectively) (Figure 1A). This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).