HIC1 and colorectal carcinoma: Finally, Janeckova and coworkers noticed a significant overlap between the genes up-regulated in the HIC1-high CRC subtype they identified and the TGF-β response gene signatures in different types of stromal cells [10, 41] and concluded that, at least in some CRCs, HIC1 is expressed in the stroma rather than in epithelial tumor cells.