The demonstrated results suggested that in ACC, genes of inflammatory pathways were upregulated such as TNF1 as wells as interleukin 1 and 6 receptors and mediators (e.g., IRAK 2, 3, IL1B, JAK3, STAT1, STAT4) (Supplementary Figure 1C). This evidence concerns the gene STAT4 and adrenal cortex carcinoma.