SFRP4 and neoplasm: The divergent gene expression pattern between tumor and non-tumor area of the mucoepidermoid carcinomas shows, as demonstrated in Figure 3A and Table 2A, a clear upregulation of COMP. Similarly, some Wnt pathway genes such as WNT7B, FZD10 and SFRP4 are significantly overexpressed, whereas WIF1, CXXC4, PLCB1 and 4 are downregulated.