PLCB4 and neoplasm: As shown in Figure 4A, the analysis of the corresponding tumor and non-tumor samples also revealed upregulation of COMP, matrix proteins such as COL5A1, COL11A1, and FN1, and genes of the Wnt pathway (WNT7B, FZD10, SFRP2), while PLCB1, CAMK2B, PLCB4 and WIF1 are downregulated (Table 3A).